Frontline

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs 3 Treatments

$35.34$44.99

720+ bought in the past month

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
$35.34
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Product details
BrandFrontline
Item FormLiquid
ScentUnscented
Item Weight0.04 Pounds
Active Ingredientsfipronil and (S)-methoprene
Item Volume339 Milliliters
Allergen InformationAbalone Free
Dog Breed SizeLarge
Age Range (Description)All Life Stages
UPC350604287209 666672366389
Technical specifications
is_discontinued_by_manufacturerNo
product_dimensions5.75 x 0.75 x 4.5 inches; 0.64 ounces
manufacturer_recommended_age1 month and up
item_model_number72219
departmentInsect Control
date_first_availableSeptember 2, 2004
manufacturerBoehringer Ingelheim Animal Health
best_sellers_rank#198 in Pet Supplies ( See Top 100 in Pet Supplies ) #2 in Dog Flea Drops

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Customer reviews

4.449,699 ratings
  1. 583%
  2. 417%
  3. 30%
  4. 20%
  5. 10%

Customers say

Customers find this pest control product to be the best for fighting fleas and ticks, with easy application along the back.

★★★★★

Finally found something that actually works!

Rob & Natalie MartinezFebruary 9, 2026✓ Verified purchase

After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs! Read more

★★★★★

Works good

Eii1191March 2, 2026✓ Verified purchase

Works good. Been using for 4-5 years. My German shepherd has no problems with its use. No stinking smell. Effective my dog doesn’t scratch. Easy to apply. Recommended Read more

★★★★★

This stuff works!

MikaylaMarch 4, 2026✓ Verified purchase

This product gets the job done! My dogs have never had a flea or a tick while using this treatment. It's an excellent preventative. I've tried other treatments that just don't work, and I always come back to Frontline. It's easy to use. It is a little greasy when you first put it on, but that's to be expected, and it dries up by the next day. Read more

★★★★☆

May have worked

kristineJanuary 7, 2026✓ Verified purchase

I think may have worked for my dogs . The only thing I have a complaint about is that the treatment itself is not enough I have two dogs and I had to use all three of these on them from between their shoulder blades to their tail. I’ve haven’t seen any fleas on them since using this but I’m not sure . Read more

★★★★★

Frontline Defense

Aurora BlizzardFebruary 21, 2026✓ Verified purchase

Works very well. Buying a lesser off brand or generic brand isn't worth it. Frontline is the best. Caution: make sure to buy the proper dose for your dog according to their weight. It is better &, safer to under dose and underestimate than to ever estimate. If your dog as a tick infestation you will have to remove the dead ticks with a tick removal device & bathe the dog afterwards. Their product is worth every penny & more. Don't waste your money on Genetic substitutions in in this case. Keeps dog & companion animals happy & healthy Read more

★★★★★

Thank God!

KarlaJamaicaAugust 16, 2013✓ Verified purchase

I have two Malteses and they had SERIOUS fleas. One of my poor babies was simply crawling and could not go long without scratching. I tried the Little City Dogs products last month (both the Capsar knockoff and the Program knockoff) and neither did a thing. I didn't want to use another product immediately, so I waited a long month to buy Frontline Plus. I have used Frontline Plus successfully in the past, but the price gave me pause this time around. I had also heard that the product was becoming less effective. That does not seem to be the case for the fleas in my neck of the woods (and by neck of the woods I mean Philadelphia). 24 hours after applying Frontline Plus one of my dogs was flea free and the other had slow-moving fleas. It looked like a flea death march. 48 hours after applying the product both are free of live fleas and look much more comfortable. One still has flea dust which I will comb out later today. I did purchase the product for large dogs and distributed an appropriately sized dose to each of my small dogs. This was a cost saving measure that I am NOT recommending to others as I am not a vet. So, this batch would last me three months for both dogs. I discard the extra in the vial. Important Notes: (1) Do not wash your dog for at least a few days prior to treatment. The sweat in the hair and on the skin helps the product to adhere. (2) Do not wash your dogs for at least a few days after treatment for this same reason. (3) Read the box carefully, and return it if you see any red flags (i.e. product name on vial does not match box) Also, in response to the "Buyer Beware" posted on 10/15/12. My product has none of the issues that this reviewer mentioned. 1. I did receive calendar stickers with the product. 2. The back of the vial was properly labeled "Frontline Plus" 3. My vials were sealed appropriately (and were quite difficult to open). I didn't check my lot number, but all in all this product seems fully legitimate to me. Read more

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