Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition

1929+ bought in the past month

$21.97

About this item

  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
$21.97

In Stock

DeliveryEstimated 3–5 business days · Final delivery speed and cost are confirmed at checkout
Easy Returns · 30-day window
This order is a gift

In Stock

Secure Checkout
Free Returns
30-Day Guarantee
Secure checkoutAll transactions are SSL-encrypted. Your payment info is never stored.
Free returnsReturn or replace within 30 days
Fast deliveryOrders ship within 1 business day and arrive in 4–8 days.
Buyer protectionIf your order arrives damaged or doesn't show up, we'll make it right.
24/7 supportOur team is here to help. Reach us anytime by email or chat.
Ships fromOur Warehouse
Sold byTriquetra Health
Returns
Easy Returns30-day return window
PaymentsSecure transaction
Currently unavailable
Easy Returns · 30-day window

Product details

BrandTriquetra Health
Item FormCapsule
Primary Supplement TypeVitamin B12
Diet TypeGluten Free
FlavorUnflavored

Technical specifications

date_first_availableJune 25, 2021
manufacturerTriquetra Health
best_sellers_rank#294 in Health & Household ( See Top 100 in Health & Household ) #1 in Vitamin B9 (Folic Acid) Supplements

From the brand

Product detailProduct detailProduct detailProduct detailProduct detailProduct detailProduct detail
Product detailProduct detailProduct detailProduct detailProduct detail

Product videos

Product video 1

Customer reviews

4.512,521 ratings

Customers say

Customers find this vitamin supplement to be of high quality and effective, reporting great results within a short time. Customers report positive effects on mood, with some mentioning it almost eliminates anxiety completely, and they feel better overall, with one noting it doesn't cause jitteriness or stomach upset.

★★★★★

Easy-to-Take Active B-Vitamins with a Noticeably Calming Effect

Adrian JuarezDecember 23, 2025

This is a well-formulated supplement. The berry flavor is mild and pleasant, and the sublingual format makes it easy to take, especially for anyone who prefers not to swallow pills. With consistent use, I noticed I felt more calm and balanced, particularly during periods of increased sensory input. It did not cause stomach discomfort or an overstimulating effect, which I appreciate given the strength of the formula. I first learned about this product through TikTok, where it was being discussed within autism and ADHD communities, and decided to try it for myself. Overall, I’m very satisfied with the quality and effectiveness and would purchase it again. Those new to methylated B-vitamins may want to start with a smaller amount due to the potency. Read more

★★★★★

Noticeable energy and mood support.

KambukoNovember 28, 2025

I started taking L-Methylfolate plus Methyl B-12 after my doctor recommended it following a MTHFR genetic test. The test showed that I have a variant that makes it harder for my body to convert folic acid into its active form. Since starting this supplement, I have noticed a clear improvement in my energy levels and mental clarity. It took a little patience, but by the third week I really started to feel the effects. I feel less drained during the day and more focused on tasks. I like that this product comes in liquid form, which is easy to take and absorbs quickly. The taste is surprisingly sweet, which makes it pleasant to take and not at all medicinal. This supplement combines L-Methylfolate, the active form of folate, with Methyl B-12, which is highly bioavailable. For someone with an MTHFR variant, this form feels more effective than regular folic acid and standard B12. In addition to supporting energy, B12 also helps with healthy nerve function, red blood cell formation, and overall cognitive health. It feels like a comprehensive boost for both body and mind. One thing to note is that it may take a couple of weeks to feel the effects, so patience is important. The price is reasonable considering the quality and the multiple benefits it provides. Overall, I am very happy with this supplement and plan to continue taking it. The liquid form, surprisingly sweet taste, and noticeable improvement in energy, focus, and overall wellness make it a product I genuinely recommend. Read more

Review image 1Review image 2Review image 3
★★★★★

Missing piece to enhance my medication!

Andrea GarcíaNovember 7, 2025

This is amazing! I bought this in May, but I was hesitant about taking it because I wanted to consult this with my primary care doctor since I’m on depression-anxiety and ADHD medications, fast forward to a week ago, I had an appointment, I asked and I had a green light to take this supplement as an addition to my medication, and I have to say that THIS IS WHAT I NEEDED! This is what was missing. The medication is doing a great job, however this supplement is an amazing addition. I feel great! Even more energized and my mood improved significantly. I was advised to start taking it slowly and in the morning, starting at 2 drops the first day, then 4 and so on until I got to 10. Since the first 2 drops I started seeing results. I think that the outcome depends on each individual, we all are different and what works for me might not for you, but give it a try! Consult with your doctor first though. Read more

★★★★★

Easy, and can stretch to 600 doses

Human FemaleNovember 21, 2025

This product almost seems too good to be true. Serving size is 10 drops but I just take 1 because it's still MANY times what I need for daily value. No crap ingredients, methylated version of both folate and B12. What's not to like? Easy to use, no belly issues, tastes great. Can't tell how well it works because it's a vitamin, but I have the MTHF gene issue, so I know I need it. Read more

★★★★☆

Pills

ThomasDecember 21, 2025

It’s easy to swallow and a great dosage. Very effective at delivering the product into my body. Read more

★★★★★

Great supplement

Lynn C. SnyderDecember 28, 2025

This really gives me a boost in the morning and takes away the mental fog. My daughter takes it for ADHD instead of adderal and likes it better. Read more

★★★★★

Good quality supplement

MomandersonDecember 20, 2025

I have been using this brand of this supplement for about a year. It is a good quality supplement for a good price. We have experienced no problems or side effects. We will order it again. Read more

★★★☆☆

The jury is out on this one

Ashley BurtNovember 16, 2025

I dont see much of a difference. I even tried taking 15 drops a day directly on my tongue. I even let it sit to see if it will absorb more sublingually before swallowing. I also shake well first per the instructions on the bottle. I already take adderall for adhd, I exercise regularly 3-5 days a week pretty high intensity cardio and strength training. I have a high caffeine tolerance too. So i dont know if maybe im just maxed on stimulants right now that any further energy boost isnt noticeable? I can take my daily adderall, pre workout, espresso, 1-2 energy drinks and i tolerate it and have for years. My main issue is as a mom going into her 40s i feel like im dragging by the end of the day and still low motivation and general overall satisfaction in daily life that is a struggle each and every day. I constantly practice breath work, qigong, meditation, and all the mental housekeeping and energy flow methods i can find that help. I still feel like i cant keep my eyes away past 8-9 pm and constantly like my candle is burning at both ends. And yes my magnesium levels are normal. None of my labs are out of normal limits. I take regular daily vitamins too. I feel a very subtle uptick in relaxation. But its nothing like what people are going on and on about how this is a “game changer”. I feel like regular exercise and activity is more beneficial than this one single supplement. Read more

Recently Viewed