Omne Diem

Omne Diem DAO 30 000 HDU - 60 Caps - Histamine Neutralizing Enzyme - Relieve Histamine Intolerance with

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$54.95

About this item

  • Powerful Histamine Support with Natural DAO Enzyme – OmneDiem Histamine Digest provides 30,000 HDU of Diamine Oxidase (DAO) per serving, a crucial enzyme responsible for breaking down histamine in the gut. This high-potency formula helps individuals with histamine intolerance enjoy a wider variety of foods without unwanted reactions. By targeting histamine directly in the digestive tract, it reduces symptoms like flushing, bloating, nasal congestion, and headaches caused by histamine-rich foods, promoting overall digestive and immune health.
  • Combat Histamine Sensitivity & Enhance Digestion – Designed for those sensitive to histamine, OmneDiem Histamine Digest helps mitigate histamine-induced discomfort before it starts. DAO works by degrading excess histamine from food, preventing it from triggering adverse reactions. Whether you're sensitive to aged cheeses, fermented foods, red wine, or cured meats, this supplement provides essential support to ease gastric distress, inflammation, and other histamine-related symptoms, ensuring greater meal tolerance.
  • Fast-Acting Formula for Immediate Relief – Unlike general digestive enzymes, DAO targets histamine degradation at the source, working within 20 minutes of ingestion. Simply take it before consuming histamine-rich foods to help prevent symptoms like stomach pain, itching, dizziness, or skin reactions. The rapid-release vegetarian capsules ensure quick absorption, making it an effective tool for maintaining digestive balance, supporting gut health, and improving food tolerance in those with histamine intolerance.
  • Non-Systemic & Clinically Proven for Safety – OmneDiem Histamine Digest is formulated with clinically tested DAO, acting exclusively in the digestive tract without affecting overall histamine levels in the body. Unlike antihistamines, which block histamine receptors, DAO naturally breaks down histamine without entering the bloodstream. This non-systemic, side-effect-free approach makes it a safe and reliable solution for daily histamine intolerance management, improving overall gut function and well-being.
  • Supports a Balanced Diet & Quality of Life – Histamine intolerance can limit food choices and impact daily comfort, but OmneDiem Histamine Digest allows for greater dietary freedom. By reducing histamine overload, it helps alleviate common symptoms such as flushing, nasal congestion, digestive disturbances, and skin reactions, allowing you to enjoy meals without worry. Whether you’re dining out or following a histamine-restricted diet, this DAO supplement provides the digestive support needed for optimal health and well-being.
$54.95

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Product details

BrandOmne Diem
FlavorUnflavored
Primary Supplement TypeDAO Enzyme
Unit Count60 Count
Item FormCapsule
Item dimensions L x W x H2.2 x 2.2 x 3 inches
Special IngredientsDiamine Oxidase Enzyme
Diet TypeGluten Free
Product BenefitsIntolerance
Age Range (Description)Child

Technical specifications

product_dimensions2.2 x 2.2 x 3 inches; 1.45 ounces
item_model_numberDAO- 30000HDU-60-Caps
date_first_availableJune 7, 2021
manufacturerOmne Diem Direct
best_sellers_rank#43,430 in Health & Household ( See Top 100 in Health & Household ) #183 in Multi-Enzyme Nutritional Supplements

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Customer reviews

4.2650 ratings

Customers say

Customers report that the enzyme supplement works immediately and helps with histamine intolerance, with one noting it's effective even after eating.

★★★★★

It is pricey but worth it, because it works!

ShelleyOctober 9, 2025

One Diem DAO 30,000 is an excellent product that my functional medicine doctor recommended for my food allergies. It helps with the histamine reaction to foods. I take it on a regular basis 3 times a day. It even helps to unclog my ears. I am very happy with it. Read more

★★★★★

Histamine Intolerance

Susan M. BerryJuly 14, 2025

This product helps me eat like a "normal" person. It is the enzyme that you naturally produce that breaks down histamine in your digestive system. One theory is that people with mast cells issues don't make enough of it. This is the absolutely necessary supplement for food intolerances. It does not work for people who have true IGE allergies to food. Wanted to make that clear. Read more

★★★★★

Seems to work well for me

Cat peepJune 6, 2025

Seems to work well. Haven’t used it long enough to be sure. I try to really limit the histamine foods I eat, so it’s hard to say if I’m getting better at that or if it’s the supplement. But it really DOES seem to make me feel better. And I do know for certain it prevented a histamine reaction from one meal. So, I do recommend trying it. I’m now certain I do have histamine sensitivity. Read more

★★★★☆

Works for MCAS

OriOctober 19, 2022

I have Mast Cell Activation Syndrome. I had read some reviews that this product helped other patients with my disease. MCAS is more than *just* food allergies, so this DAO vitamin won't help with chemical and environmental allergies due to MCAS, but it does however help to some extent with my food allergies. I will say that it is good to take this around 15-30 minutes before eating. I am less reactive to foods that I am normally more reactive to, when I take these pills. People with MCAS usually have a DAO deficiency, which is why this vitamin is so helpful. Just one pill alone is usually not enough. I read some reviews on MCAS website about this product and they suggested taking anywhere from 2-5 pills before each meal depending on severity of the histamine content in the food. 2 or 3 pills is what I usually do and thats what seems to work best for me personally. I have already bought a second bottle because it works so well. It is expensive but WORTH the price for histamine intolerance. Read more

★☆☆☆☆

Contains ascorbyl palmitate! Beware!

CustomerDecember 9, 2025

Do not use this supplement if your histamine intolerance is severe! It contains ascorbyl palmitate, which is often derived from fermented corn or tapioca. It can also contain residual mold spores from the fermentation process. I had a strong histamine response to this supplement, which caused tight chest, breathing difficulty, and chest pain. Read more

★★★★★

IT WORKS!! Knocks down histamine in the gut!

InParadiseNowJanuary 11, 2022

Between high histamine levels and immune disease I must carefully select supplements with full review of active and inactive ingredients prior to purchase. I react to all nightshades, legumes, citrus, nuts and much more. For 10 years I would often wake in the morning to a very swollen face, hands and gut with nasty malaise and great exhaustion!?!? I learned from a Mast Cell Specialist about the high histamine gut and eliminating high histamine foods. With IBS that lead to SBO (that I can't take antibiotics or probiotics for due to reactions) that wiped out one of the two enzymes in the gut that blocks histamine you end up with swelling. The mystery was it usually hit overnight while sleeping or within 10 minutes of waking???? Histamine rises at night and first thing in the morning!! Bingo after 10 years of hiding half the day due to swelling and feeling terrible I finally have it under control because of this supplement. Every now and again I will wake to a swollen face but the incidence of this happening has dropped 95% since it started taking this supplement twice a day when I eat. It has made a remarkable difference in my quality of life and have taken it every day for 4 months. i plan to stay on it for years to come. it really works for me and I hope it works for you, but like many supplements you need to find what works best for you and your system. I like the product very much, its not full of extra stuff I don't want or need and it works great. Read more

★★★★★

Amazing. Helps dramatically with my allergies and inflammation!

L.B.September 8, 2025

Amazing. Helps dramatically with my allergies and inflammation. More than I could imagine Read more

★★★★★

It works

carol gibsonAugust 2, 2025

I have been taking this product for a little over thirty days and I have been able to tell a big difference.. Read more

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